Yves Agid

Les travaux d’Yves Agid et de ses collaborateurs ont donné lieu à la publication de plus de 700 articles scientifiques, dans des revues spécialisées de neurologie, mais également dans des revues scientifiques généralistes prestigieuses. C’est le neuroscientifique français le plus cité de ces 30 dernières années et le deuxième le plus cité au monde dans le domaine de la maladie de Parkinson

Publications les plus significatives

• Agid Y, Javoy F, Glowinski J. Hyperactivity of remaining dopaminergic neurons after partial destruction of the nigrostriatal dopaminergic system in the rat. Nat New Biol 245: 150-151, 1973.
• Agid Y, Pollak P, Bonnet Am, Signoret Jl, Lhermitte F. Bromocriptine associated with a peripheral dopamine blocking agent in the treatment of Parkinson’s disease. Lancet 17: 570-572, 1979.
• Graybiel Am, Hirsch Ec, Agid Y. Differences in tyrosine hydroxylase-like immureactivity characterize the mesostriatal innvervation of striosomes and extrastriosomal matrix at matury. Proc Natl Acad Sci USA 84: 303-7, 1987.
• Hirsch E, Graybiel AM, Agid Y. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334: 345-8, 1988.
• Lehericy S, Hirsch EC, Cervera P, Hersh LB, Hauw JJ, Ruberg M, Agid Y. Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease. Proc Natl Acad Sci USA 86: 8580-4, 1989.
• Agid Y. Parkinson's disease: pathophysiology. Lancet 337: 1321-4, 1991.
• Faucheux BA, Nillesse N, Damier P, Spik G, Mouatt-Prigent A, Pierce A, Leveugle B, Kubis N, Hauw JJ, Agid Y. Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson’s disease. Proc Natl Acad Sci USA 92: 9603-7, 1995.
• Durr A, Cossee M, Agid Y, Campuzano V, Mignard C, Penet C, Mandel JL, Brice A, Koenig M. Clinical and genetic abnormalities in patients with Friedreich ataxia. New Engl J Med 335: 1169-75, 1996.
• Sirigu A, Duhamel JR, Cohen L, Pillon B, Dubois B, Agid Y. The mental representation of hand movements after parietal cortex damage. Science 273: 1564-8, 1996.
• Hunot S, Brugg B, Ricard D, Michel PP, Muriel MP, Ruberg M, Faucheux BA, Agid Y. Hirsch EC. Nuclear translocation of NF-kB is increased in dopaminergic neurons of patients with Parkinson disease. Proc Natl Acad Sci USA 94:7531-6, 1997.
• David G, Abbas N, Stevanin G, Durr A, Yvert G, Cancel G, Weber C, Imbert G, Saudou F, Antoniou E, Drabkin H, Gemmill R, Giunti P, Benomar A, Wood N, Ruberg M, Agid Y, Mandel JL, Brice A. Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion. Nat Genet 17: 65-70, 1997.
• Bejjani BP, Damier P, Arnulf I, Thivard L, Bonnet AM, Dormont D, Cornu P, Pidoux B, Samson, Agid Y. Transient acute depression induced by high-frequency deep-brain stimulation. New Engl J Med 340:1476-80, 1999.
• Lucking CB, Durr A, Bonifati V, Vaughan J, De Michele G, Gasser T, Harhangi BS, Meco G, Denefle P, Wood NW, Agid Y, Brice A; French Parkinson's Disease Genetics Study Group. European Consortium on Genetic Susceptibility in Parkinson's Disease. Association between early-onset Parkinson's disease and mutations in the parkin gene. New Engl J Med 342: 1560-7, 2000.
• Mallet L, Mesnage V, Houeto JL, Pelissolo A, Yelnik J, Behar C, Gargiulo M, Welter ML, Bonnet AM, Pillon B, Cornu P, Dormont D, Pidoux B, Allilaire JF, Agid Y. Compulsions, Parkinson’s disease and stimulation. Lancet 360: 1302-4, 2002.
• Ibanez P, Lohmann E, Pollak P, Durif F, Tranchant C, Agid Y, Durr A, Brice A; French Parkinson's Disease Genetics Study Group. Absence of NR4A2 exon 1 mutations in 108 families with autosomal dominant Parkinson disease. Lancet 62: 2133-2134, 2004.
• Vidailhet M, Vercueil L, Houeto JL, Krystkowiak P, Benabid AL, Cornu P, Lagrange C, Tezenas du Montcel S, Dormont D, Grand S, Blond S, Detante O, Pillon B, Ardouin C, Agid Y, Destee A, Pollak P. French Stimulation du Pallidum Interne dans la Dystonie (SPIDY) Study Group. Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. New Engl J Med 352: 459-67, 2005.
• Vidailhet M, Vercueil L, Houeto JL, Krystkowiak P, Lagrange C, Yelnik J, Bardinet E, Benabid AL, Navarro S, Dormont D, Grand S, Blond S, Ardouin C, Pillon B, Dujardin K, Hahn-Barma V, Agid Y, Destee A, Pollak P; French SPIDY Study Group. Bilateral pallidal deep brain stimulation in primary generalized dystonia: a prospective controlled three year follow-up. Lancet Neurol 6: 223-9, 2007.
• Yelnik J, Bardinet E, Dormont D, Malandain G, Ourselin S, Tande D, Karachi C, Ayache N, Cornu P, Agid Y. Atlas construction based on immunohistochemical and MRI data. Neuroimage 34: 618-638, 2007.
• Mallet L, Schüpbach M, N’Diaye K, Remy P, Bardinet E, Czernecki V, Welter ML, Pelissolo A, Agid Y, Yelnik J. Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior. Proc Natl Acad Sci USA 19; 104(25): 10661-6, 2007.
• Welter ML, Mallet L, Houeto JL, Karachi C, Czernecki V, Cornu P, Navarro S, Pidoux B, Dormont D, Bardinet E, Yelnik J, Damier P, Agid Y. Internal pallidal and thalamic stimulation in patients with Tourette syndrome. Arch Neurol 65(7): 952-7, 2008.
• Bardinet E, Bhattacharjee M, Dormont D, Pidoux B, Malandain G, Schüpbach M, Ayache N, Cornu P, Agid Y, Yelnik J. A three-dimensional histological atlas of the human basal ganglia. II. Atlas deformation strategy and evaluation in deep brain stimulation for Parkinson disease. J Neurosurg 110(2): 208-19, 2009.
• Bardinet E, Bhattacharjee M, Dormont D, Pidoux B, Malandain G, Schüpbach M, Ayache N, Cornu P, Agid Y, Yelnik J. A three-dimensional histological atlas of the human basal ganglia. II. Atlas deformation strategy and evaluation in deep brain stimulation for Parkinson disease. J Neurosurg 110(2): 208-19, 2009.
• Bensimon G, Ludolph A, Agid Y, Vidailhet M, Payan C, Leigh PN; NNIPPS Study Group. Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain 132(Pt 1): 156-71, 2009.
• Vidailhet M, Yelnik J, Lagrange C, Fraix V, Grabli D, Thobois S, Burbaud P, Welter ML, Xie-Brustolin J, Braga MC, Ardouin C, Czernecki V, Klinger H, Chabardes S, Seigneuret E, Mertens P, Cuny E, Navarro S, Cornu P, Benabid AL, Le Bas JF, Dormont D, Hermier M, Dujardin K, Blond S, Krystkowiak P, Destée A, Bardinet E, Agid Y, Krack P, Broussolle E, Pollak P; French SPIDY-2 Study Group. Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia- Group. Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study. Lancet Neurol. 8(8): 709-17, 2009.
• Ribeiro MJ, Thobois S, Lohmann E, du Montcel ST, Lesage S, Pelissolo A, Dubois B, Mallet L, Pollak P, Agid Y, Broussolle E, Brice A, Remy P; French Parkinson's Disease Genetics Study Group. A multitracer dopaminergic PET study of young-onset parkinsonian patients with and without parkin gene mutations. J Nucl Med 50(8):1244-50, 2009. Epub 2009 Jul 17, 2009
• Al-Chalabi A, Dürr A, Wood NW, Parkinson MH, Camuzat A, Hulot JS, Morrison KE, Renton A, Sussmuth SD, Landwehrmeyer BG, Ludolph A, Agid Y, Brice A, Leigh PN, Bensimon G; NNIPPS Genetic Study Group. Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy. PLoS One 22;4(9): e7114, 2009.
• Brown RG, Lacomblez L, Landwehrmeyer BG, Bak T, Uttner I, Dubois B, Agid Y, Ludolph A, Bensimon G, Payan C, Leigh NP; NNIPPS Study Group. Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain 133(Pt 8):2382-93, 2010. Epub 2010.
• Worbe Y, Mallet L, Golmard JL, Béhar C, Durif F, Jalenques I, Damier P, Derkinderen P, Pollak P, Anheim M, Broussolle E, Xie J, Mesnage V, Mondon K, Viallet F, Jedynak P, Ben Djebara M, Schüpbach M, Pelissolo A, Vidailhet M, Agid Y, Houeto JL, Hartmann A. Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both? PLoS One 24; 5(9): e12959, 2010. 
• Agid Y, Buzsaki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, Lambert JJ, Manji H, Mayberg H, Popoli M, Prochiantz A, et al. How can drug discovery for psychiatric disorders be improved? Nature 6: 189-201, 2007. Review. 
• Mallet L, Polosan M, Jaafari N, Baup N, Welter ML, Fontaine D, Tezenas Du Montcel, Yelnik J, Chereau I, Arbus C, et al, for the French “Stimulation dans le Trouble Obsessionnel Compulsif (STOC)” Study Group. A randomized trial of high frequency subthalamic nucleus stimulation in severe refractory obsessive compulsive disorder. New Engl J Med 359(20: 2121-34, 2008.
• Vidailhet M, Yelnok J, Lagrange C, Fraix V, Grabli D, Thobois S, Burbaud P, Welter ML, Xie-Brustolin J, Coelho Braga MC, Ardouin C, Czernecki V, et al, for the French SPIDY-2 Study Group. Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study. Lancet Neurol 8, 709-717, 2009.
• Redgrave P, Rodriguez M, Smith Y, Rodriguez-Oroz MC, Lehericy S, Bergman H, Agid Y, Delong MR, Obeso  JA. Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease. Nat Rev Neurosci (11): 760-72, 2010.
• Millan MJ, Agid Y, Brune M, Bullmore ET, Carter CS, Clayton NS, Connor R, Davis S, Deakin B, Derubeis RJ, Dubois B, Geyer MA, et al. Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov 11(2): 141-68, 2012.
• Welter ML, Schüpbach M, Czernecki V, Karachi C, Fernandez-Vidal S, Golmard JL, Serra G, Navarro S, Welaratne A, Hartmann A, Mesnage V, Pineau F et al. Optimal target localization for subthalamic stimulation in patients with Parkinson disease. Neurology. 2014 ; 82(15):1352-61.