Pierre Douzou

Les travaux de Pierre Douzou et de ses collaborateurs ont donné lieu à la publication de près de 130 articles originaux et à des ouvrages, notamment de culture scientifique.

Principales publications

• Ptak M, Douzou P. Examination of optically excited amino-acids by electron spin resonance at very low temperature. Nature 199: 1092, 1963.
• Helene C, Douzou P, Michelson AM. Energy transfer in dinucleotides. Proc Natl Acad Sci USA 55: 376-81, 1966.
• Banerjee R, Douzou P, Lombard A. Kinetics of association of carbon monoxide with haemoglobin at low temperature. Nature 217: 23-5, 1968.
• Leterrier F, Douzou P. Photoprocesses and molecular associations. Photochem Photobiol 8: 369-81, 1968.
• Balny C, Canva J, Douzou P, Bourdon J. Chemiluminescence and energy transfer from singlet oxygen pairs. Photochem Photobiol 10: 375-82, 1969.
• Travers F, Michelson AM, Douzou P. Low-temperature studies of polynucleotides. Biochim Biophys Acta 199: 29-35, 1970.
• Possani LD, Banerjee R, Balny C, Douzou P. Oxidation of haemoglobin by oxygen in light: possible role of singlet oxygen. Nature 226: 861-2, 1970.
• Douzou P, Sireix R, Travers F. Temporal resolution of individual steps in an enzymic reaction at low temperature. Proc Natl Acad Sci U S A 66: 787-92, 1970.
• Balny C, Debey P, Douzou P. Reversible suspension of metabolism in subcellular organelles in "antifreeze" media at sub-zero temperatures. Cryobiology 9: 465-8, 1972.
• Hui-Bon-Hoa G, Douzou P. Ionic strength and protonic activity of supercooled solutions used in experiments with enzyme systems. J Biol Chem 248: 4649-54, 1973.
• Debey P, Balny C, Douzou P. Enzyme assay in microsomes below zero degrees. Proc Natl Acad Sci USA 70: 2633-6, 1973.
• Douzou P. The use of subzero temperatures in biochemistry : slow reactions. Methods Biochem Anal 22: 401-512, 1974.
• Maurel P, Douzou P. Solvent-temperature perturbations of ionizable groups as a tool for the investigation of the active site of enzymes. J Biol Chem 250: 2678-80, 1975.
• Douzou P, Hoa GH, Petsko GA. Protein crystallography at sub-zero temperatures: lysozyme-substrate complexes in cooled mixed solvents. J Mol Biol 96: 367-80, 1975.
• Douzou P. Enzymology at subzero temperatures. Adv Enzymol Relat Areas Mol Biol 45: 157-272, 1977.
• Douzou P, Balny C. Cryoenzymology in mixed solvents without cosolvent effects on enzyme specific activity. Proc Natl Acad Sci USA 74(6): 2297-300, 1977 Jun.
• Douzou P, Debey P, Franks F. Enzymology in supercooled water. Nature 268: 466, 1977.
• Douzou P, Keh E, Balny C. Cryoenzymology in aqueous media: Micellar solubilized water clusters. Proc Natl Acad Sci USA 76(2): 681-684, 1979 Feb;.
• Douzou P. Developments in low-temperature biochemistry and biology. Proc R Soc Lond B Biol Sci 217: 1-28, 1982.
• Balny C, Douzou P. Enzyme studies at subzero temperatures using immobilized substrates. Methods Enzymol 135: 528-36, 1987.
• Douzou P. Biological macromolecules as gels: functional similarities. Proc Natl Acad Sci USA 84: 6741-4, 1987.
• Di Primo C, Hui Bon Hoa G, Douzou P, Sligar S. Mutagenesis of a single hydrogen bond in cytochrome P-450 alters cation binding and heme solvation. J Biol Chem 265: 5361-3, 1990. Erratum in: J Biol Chem 265:16704, 1990.
• Douzou P. Osmotic regulation of gene action. Proc Natl Acad Sci USA 91: 1657-61, 1994.
• Di Primo C, Deprez E, Hoa GH, Douzou P. Antagonistic effects of hydrostatic pressure and osmotic pressure on cytochrome P-450cam spin transition. Biophys J 68: 2056-61, 1995.
• Ptak M, Douzou P. Examination of optically excited amino-acids by electron spin resonance at very low temperature. Nature 199:1092, 1963.
• Helene C, Douzou P, Michelson AM. Energy transfer in dinucleotides. Proc Natl Acad Sci USA 55: 376-81, 1966.
• Banerjee R, Douzou P, Lombard A. Kinetics of association of carbon monoxide with haemoglobin at low temperature. Nature 217:23-5, 1968.
• Leterrier F, Douzou P. Photoprocesses and molecular associations. Photochem Photobiol 8: 369-81, 1968.
• Balny C, Canva J, Douzou P, Bourdon J. Chemiluminescence and energy transfer from singlet oxygen pairs. Photochem Photobiol 10: 375-82, 1969.
• Travers F, Michelson AM, Douzou P. Low-temperature studies of polynucleotides. Biochim Biophys Acta 199: 29-35, 1970.
• Possani LD, Banerjee R, Balny C, Douzou P. Oxidation of haemoglobin by oxygen in light: possible role of singlet oxygen. Nature 226: 861-2, 1970.
• Douzou P, Sireix R, Travers F. Temporal resolution of individual steps in an enzymic reaction at low temperature. Proc Natl Acad Sci USA 66: 787-92, 1970.
• Balny C, Debey P, Douzou P. Reversible suspension of metabolism in subcellular organelles in "antifreeze" media at sub-zero temperatures. Cryobiology 9: 465-8, 1972.
• Hui-Bon-Hoa G, Douzou P. Ionic strength and protonic activity of supercooled solutions used in experiments with enzyme systems. J Biol Chem 248: 4649-54, 1973.
• Debey P, Balny C, Douzou P. Enzyme assay in microsomes below zero degrees. Proc Natl Acad Sci USA 70: 2633-6, 1973.
• Douzou P. The use of subzero temperatures in biochemistry : slow reactions. Methods Biochem Anal 22: 401-512, 1974.
• Maurel P, Douzou P. Solvent-temperature perturbations of ionizable groups as a tool for the investigation of the active site of enzymes. J Biol Chem 250: 2678-80, 1975.
• Douzou P, Hoa GH, Petsko GA. Protein crystallography at sub-zero temperatures: lysozyme-substrate complexes in cooled mixed solvents. J Mol Biol 96: 367-80, 1975.
• Douzou P. Enzymology at subzero temperatures. Adv Enzymol Relat Areas Mol Biol 45: 157-272, 1977.
• Douzou P, Balny C. Cryoenzymology in mixed solvents without cosolvent effects on enzyme specific activity. Proc Natl Acad Sci USA 74(6): 2297-300, 1977 Jun.
• Douzou P, Debey P, Franks F. Enzymology in supercooled water. Nature 268: 466, 1977.
• Douzou P, Keh E, Balny C. Cryoenzymology in aqueous media: Micellar solubilized water clusters. Proc Natl Acad Sci USA 76(2):681-684, 1979 Feb.
• Douzou P. Developments in low-temperature biochemistry and biology. Proc R Soc Lond B Biol Sci 217: 1-28, 1982.
• Balny C, Douzou P. Enzyme studies at subzero temperatures using immobilized substrates. Methods Enzymol135: 528-36, 1987.
• Douzou P. Biological macromolecules as gels: functional similarities. Proc Natl Acad Sci USA 84: 6741-4, 1987.
• Douzou P. Osmotic regulation of gene action. Proc Natl Acad Sci USA 91:1657-61, 1994.
• Di Primo C, Deprez E, Hoa GH, Douzou P. Antagonistic effects of hydrostatic pressure and osmotic pressure on cytochrome P-450cam spin transition. Biophys J 68: 2056-61, 1995.

Ouvrage scientifique

Douzou P. Cryobiochemistry: An introduction. Academic Press, Londres, 1977.

Ouvrages de culture scientifique

• Douzou P. Le chaud et le froid. Les conflits du vivant. Fayard, Paris, 1984.
• Douzou P. Les bricoleurs du septième jour – Nouveaux regards entomologiques. Fayard, Paris, 1985.
• Douzou P. Vous cherchez quoi au juste ? Odile Jacob, Paris, 1994.
• Douzou P. La saga des gènes racontée aux jeunes. Odile Jacob, Paris, 1996.
• Douzou P, Durand G, Siclet G. Les biotechnologies. Collection Que sais-je, PUF, Paris, 5e édition, 2000.